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CHKA

GENERAL INFORMATION

Gene name

 CHKA

Gene description

 Choline kinase alpha

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024153
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHKA (HGNC Symbol)

Synonyms

 CHK, CKI

Description

 Choline kinase alpha (HGNC Symbol)

Entrez gene summary

 The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 68052859 - 68121444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110721 (version 83.38)

Entrez gene

 1119

UniProt

 P35790 (UniProt - Evidence at protein level)

neXtProt

 NX_P35790

Antibodypedia

 CHKA antibodies

PROTEIN BROWSER
CHKA-001
CHKA-002
CHKA-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHKA-001
ENSP00000265689
ENST00000265689
P35790 [Direct mapping]
Choline kinase alpha
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004103 [choline kinase activity]
GO:0004104 [cholinesterase activity]
GO:0004305 [ethanolamine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006580 [ethanolamine metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006657 [CDP-choline pathway]
GO:0006869 [lipid transport]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0009636 [response to toxic substance]
GO:0016310 [phosphorylation]
GO:0019695 [choline metabolic process]
GO:0033265 [choline binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:1904681 [response to 3-methylcholanthrene]
Show all
 457 aa
52.2 kDa 		No 0
CHKA-002
ENSP00000348454
ENST00000356135
P35790 [Direct mapping]
Choline kinase alpha
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004103 [choline kinase activity]
GO:0004305 [ethanolamine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006657 [CDP-choline pathway]
GO:0006869 [lipid transport]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0016310 [phosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 439 aa
50.2 kDa 		No 0
CHKA-006
ENSP00000435032
ENST00000531341
E9PM06 [Direct mapping]
Choline kinase alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 156 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.