Cell atlas - PRPF40B - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRPF40B
Gene description	PRP40 homolog, pre-mRNA processing factor B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol, aggresome & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)
Additional location	In addition localized to the Nucleoplasm (approved), Aggresome (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038426
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol, aggresome & nucleoplasm.

Main location

Nuclear bodies (supported)

Additional location

Nucleoplasm (approved), Aggresome (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038426	A-431	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA038426	U-2 OS	Nucleoplasm
		Nuclear bodies
		Aggresome
HPA038426	U-251 MG	Nucleoplasm
		Nuclear bodies
		Cytosol

GENE INFORMATION
Gene name	PRPF40B (HGNC Symbol)
Synonyms	HYPC
Description	PRP40 homolog, pre-mRNA processing factor B (HGNC Symbol)
Entrez gene summary	This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	49568218 - 49644666
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110844 (version 83.38)
Entrez gene	25766
UniProt	Q6NWY9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NWY9
Antibodypedia	PRPF40B antibodies

PROTEIN BROWSER

PRPF40B-001	PRPF40B-002	PRPF40B-003	PRPF40B-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPF40B-001 ENSP00000369634 ENST00000380281	Q6NWY9 [Direct mapping] Pre-mRNA-processing factor 40 homolog B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005685 [U1 snRNP] GO:0016607 [nuclear speck] GO:0071004 [U2-type prespliceosome] Show all	871 aa 99.4 kDa	No	0
PRPF40B-002 ENSP00000261897 ENST00000261897	Q6NWY9 [Direct mapping] Pre-mRNA-processing factor 40 homolog B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005685 [U1 snRNP] GO:0016607 [nuclear speck] GO:0071004 [U2-type prespliceosome] Show all	858 aa 97.8 kDa	No	0
PRPF40B-003 ENSP00000449569 ENST00000551063		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
PRPF40B-019 ENSP00000448073 ENST00000548825	F8VU11 [Direct mapping] PRP40 pre-mRNA processing factor 40 homolog B (Yeast), isoform CRA_a; Pre-mRNA-processing factor 40 homolog B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	892 aa 101.4 kDa	No	0