Fields »
ABOUT
HELP
BLOG
PRMT8

GENERAL INFORMATION

Gene name

 PRMT8

Gene description

 Protein arginine methyltransferase 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, caudate, cerebellum)
FANTOM5:Group enriched (caudate, cerebellum, brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in neuronal cells.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Subcellular location is contradicted by limited external data.

Reliability score

 Approved based on 2 antibodies.
HPA039747 , HPA069769
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Prostate
N/A
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, caudate, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, brain, hippocampus)

GENE INFORMATION

Gene name

 PRMT8 (HGNC Symbol)

Synonyms

 HRMT1L3, HRMT1L4

Description

 Protein arginine methyltransferase 8 (HGNC Symbol)

Entrez gene summary

 Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 3381349 - 3593973

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111218 (version 83.38)

Entrez gene

 56341

UniProt

 Q9NR22 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR22

Antibodypedia

 PRMT8 antibodies

PROTEIN BROWSER
PRMT8-001
PRMT8-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRMT8-001
ENSP00000372067
ENST00000382622
Q9NR22 [Direct mapping]
Protein arginine N-methyltransferase 8
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043393 [regulation of protein binding]
GO:0043985 [histone H4-R3 methylation]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
GO:0046982 [protein heterodimerization activity]
Show all
 394 aa
45.3 kDa 		No 0
PRMT8-003
ENSP00000414507
ENST00000452611
Q9NR22 [Direct mapping]
Protein arginine N-methyltransferase 8
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043393 [regulation of protein binding]
GO:0043985 [histone H4-R3 methylation]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
GO:0046982 [protein heterodimerization activity]
Show all
 385 aa
44.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.