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ARPC3

CANCER ATLAS

Gene description

 Actin related protein 2/3 complex, subunit 3, 21kDa

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA006550

GENE INFORMATION

Gene name

 ARPC3 (HGNC Symbol)

Synonyms

 ARC21, p21-Arc

Description

 Actin related protein 2/3 complex, subunit 3, 21kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 110434825 - 110450422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111229 (version 83.38)

Entrez gene

 10094

UniProt

 O15145 (UniProt - Evidence at protein level)

neXtProt

 NX_O15145

Antibodypedia

 ARPC3 antibodies

PROTEIN BROWSER
ARPC3-001
ARPC3-007
ARPC3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC3-001
ENSP00000228825
ENST00000228825
O15145 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 178 aa
20.5 kDa 		No 0
ARPC3-007
ENSP00000413221
ENST00000426440
C9JZD1 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 99 aa
11.5 kDa 		No 0
ARPC3-011
ENSP00000446598
ENST00000547365
F8VR50 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 84 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.