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ARPC3

GENERAL INFORMATION

Gene name

 ARPC3

Gene description

 Actin related protein 2/3 complex, subunit 3, 21kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and/or cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA006550
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARPC3 (HGNC Symbol)

Synonyms

 ARC21, p21-Arc

Description

 Actin related protein 2/3 complex, subunit 3, 21kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 110434825 - 110450422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111229 (version 83.38)

Entrez gene

 10094

UniProt

 O15145 (UniProt - Evidence at protein level)

neXtProt

 NX_O15145

Antibodypedia

 ARPC3 antibodies

PROTEIN BROWSER
ARPC3-001
ARPC3-007
ARPC3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC3-001
ENSP00000228825
ENST00000228825
O15145 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
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 178 aa
20.5 kDa 		No 0
ARPC3-007
ENSP00000413221
ENST00000426440
C9JZD1 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 99 aa
11.5 kDa 		No 0
ARPC3-011
ENSP00000446598
ENST00000547365
F8VR50 [Direct mapping]
Actin-related protein 2/3 complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0005885 [Arp2/3 protein complex]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 84 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.