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MYL2

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GENERAL INFORMATION

Gene name

 MYL2

Gene description

 Myosin, light chain 2, regulatory, cardiac, slow

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Group enriched (U-2 OS, EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA019763
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-2 OS, EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Microtubules (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019763 A-431 Microtubules
HPA019763 U-2 OS Microtubules
HPA019763 U-251 MG Microtubules
Cytosol

GENE INFORMATION

Gene name

 MYL2 (HGNC Symbol)

Synonyms

 CMH10

Description

 Myosin, light chain 2, regulatory, cardiac, slow (HGNC Symbol)

Entrez gene summary

 Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 110910819 - 110920722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111245 (version 83.38)

Entrez gene

 4633

UniProt

 P10916 (UniProt - Evidence at protein level)

neXtProt

 NX_P10916

Antibodypedia

 MYL2 antibodies

PROTEIN BROWSER
MYL2-001
MYL2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL2-001
ENSP00000228841
ENST00000228841
P10916 [Direct mapping]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Q6IB42 [Target identity:100%; Query identity:100%]
MYL2 protein; Myosin, light polypeptide 2, regulatory, cardiac, slow, isoform CRA_a; cDNA, FLJ92288, highly similar to Homo sapiens myosin, light polypeptide 2, regulatory, cardiac, slow (MYL2), mRNA
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Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002026 [regulation of the force of heart contraction]
GO:0003007 [heart morphogenesis]
GO:0003785 [actin monomer binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006942 [regulation of striated muscle contraction]
GO:0007507 [heart development]
GO:0008307 [structural constituent of muscle]
GO:0009791 [post-embryonic development]
GO:0015629 [actin cytoskeleton]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030308 [negative regulation of cell growth]
GO:0031672 [A band]
GO:0032036 [myosin heavy chain binding]
GO:0042694 [muscle cell fate specification]
GO:0048747 [muscle fiber development]
GO:0055003 [cardiac myofibril assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060047 [heart contraction]
GO:0060048 [cardiac muscle contraction]
GO:0098735 [positive regulation of the force of heart contraction]
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 166 aa
18.8 kDa 		No 0
MYL2-006
ENSP00000447154
ENST00000548438
G3V1V8 [Direct mapping]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Myosin, light polypeptide 2, regulatory, cardiac, slow, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 152 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.