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SCNN1A

CANCER ATLAS

Gene description

 Sodium channel, non voltage gated 1 alpha subunit

Protein class

 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA012743

GENE INFORMATION

Gene name

 SCNN1A (HGNC Symbol)

Synonyms

 ENaCalpha, SCNN1

Description

 Sodium channel, non voltage gated 1 alpha subunit (HGNC Symbol)

Entrez gene summary

 Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6346843 - 6377730

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111319 (version 83.38)

Entrez gene

 6337

UniProt

 P37088 (UniProt - Evidence at protein level)

neXtProt

 NX_P37088

Antibodypedia

 SCNN1A antibodies

PROTEIN BROWSER
SCNN1A-001
SCNN1A-002
SCNN1A-003
SCNN1A-004
SCNN1A-007
SCNN1A-022

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCNN1A-001
ENSP00000228916
ENST00000228916
P37088 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031514 [motile cilium]
GO:0034220 [ion transmembrane transport]
GO:0034706 [sodium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0050699 [WW domain binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0050896 [response to stimulus]
GO:0050909 [sensory perception of taste]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 669 aa
75.7 kDa 		No 2
SCNN1A-002
ENSP00000353292
ENST00000360168
P37088 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0003779 [actin binding]
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0009897 [external side of plasma membrane]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030864 [cortical actin cytoskeleton]
GO:0031514 [motile cilium]
GO:0034220 [ion transmembrane transport]
GO:0034706 [sodium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0050699 [WW domain binding]
GO:0050878 [regulation of body fluid levels]
GO:0050891 [multicellular organismal water homeostasis]
GO:0050896 [response to stimulus]
GO:0050909 [sensory perception of taste]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 728 aa
81.9 kDa 		No 2
SCNN1A-003
ENSP00000438739
ENST00000543768
P37088 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031514 [motile cilium]
GO:0034220 [ion transmembrane transport]
GO:0034706 [sodium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0050699 [WW domain binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0050896 [response to stimulus]
GO:0050909 [sensory perception of taste]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 692 aa
78.2 kDa 		No 2
SCNN1A-004
ENSP00000440876
ENST00000540037
F5GXE6 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 369 aa
40.9 kDa 		No 1
SCNN1A-007
ENSP00000443434
ENST00000536788
F5H5F8 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 159 aa
18.1 kDa 		No 1
SCNN1A-022
ENSP00000380166
ENST00000396966
J3KPV6 [Direct mapping]
Amiloride-sensitive sodium channel subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 511 aa
59 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.