Tissue expression of SLC38A1 - Summary - The Human Protein Atlas

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SLC38A1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC38A1
Gene description	Solute carrier family 38, member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including neuronal cells in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA052272
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC38A1 (HGNC Symbol)
Synonyms	ATA1, NAT2, SAT1
Description	Solute carrier family 38, member 1 (HGNC Symbol)
Entrez gene summary	Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	46183063 - 46270017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111371 (version 83.38)
Entrez gene	81539
UniProt	Q9H2H9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2H9
Antibodypedia	SLC38A1 antibodies

PROTEIN BROWSER

SLC38A1-001	SLC38A1-002	SLC38A1-003	SLC38A1-005	SLC38A1-006	SLC38A1-009	SLC38A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A1-001 ENSP00000449756 ENST00000552197	F8VX04 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006868 [glutamine transport] GO:0007565 [female pregnancy] GO:0015171 [amino acid transmembrane transporter activity] GO:0015186 [L-glutamine transmembrane transporter activity] GO:0016020 [membrane] GO:0030424 [axon] Show all	503 aa 56.2 kDa	No	>9
SLC38A1-002 ENSP00000381634 ENST00000398637	Q9H2H9 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 A0A024R124 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0007268 [synaptic transmission] GO:0015171 [amino acid transmembrane transporter activity] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	487 aa 54 kDa	No	>9
SLC38A1-003 ENSP00000398142 ENST00000439706	Q9H2H9 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 A0A024R124 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0007268 [synaptic transmission] GO:0015171 [amino acid transmembrane transporter activity] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	487 aa 54 kDa	No	>9
SLC38A1-005 ENSP00000449607 ENST00000549049	Q9H2H9 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 A0A024R124 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0007268 [synaptic transmission] GO:0015171 [amino acid transmembrane transporter activity] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	487 aa 54 kDa	No	>9
SLC38A1-006 ENSP00000447853 ENST00000546893	Q9H2H9 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 A0A024R124 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0007268 [synaptic transmission] GO:0015171 [amino acid transmembrane transporter activity] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	487 aa 54 kDa	No	>9
SLC38A1-009 ENSP00000449744 ENST00000550173	F8VX12 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	78 aa 8.9 kDa	No	0
SLC38A1-201 ENSP00000478907 ENST00000612161	F8VX04 [Direct mapping] Sodium-coupled neutral amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	503 aa 56.2 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.