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MDM1

GENERAL INFORMATION

Gene name

 MDM1

Gene description

 Mdm1 nuclear protein

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA040411 , HPA041594
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MDM1

Synonyms

Description

 Mdm1 nuclear protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 12

Cytoband

 q15

Chromosome location (bp)

 68272443 - 68332381

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111554 (version 83.38)

Entrez gene

 56890

UniProt

 Q8TC05 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TC05

Antibodypedia

 MDM1 antibodies

PROTEIN BROWSER
MDM1-001
MDM1-002
MDM1-003
MDM1-005
MDM1-006
MDM1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MDM1-001
ENSP00000302537
ENST00000303145
Q8TC05 [Direct mapping]
Nuclear protein MDM1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0060041 [retina development in camera-type eye]
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 714 aa
80.7 kDa 		No 0
MDM1-002
ENSP00000408694
ENST00000430606
Q8TC05 [Direct mapping]
Nuclear protein MDM1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0060041 [retina development in camera-type eye]
Show all
 222 aa
25.1 kDa 		No 1
MDM1-003
ENSP00000377175
ENST00000393543
Q8TC05 [Direct mapping]
Nuclear protein MDM1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0060041 [retina development in camera-type eye]
Show all
 69 aa
7.9 kDa 		No 0
MDM1-005
ENSP00000391006
ENST00000411698
Q8TC05 [Direct mapping]
Nuclear protein MDM1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0060041 [retina development in camera-type eye]
Show all
 679 aa
76.7 kDa 		No 0
MDM1-006
ENSP00000446000
ENST00000541686
F5H529 [Direct mapping]
Nuclear protein MDM1
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Predicted intracellular proteins
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GO:0005634 [nucleus]
Show all
 280 aa
31.9 kDa 		No 0
MDM1-014
ENSP00000445181
ENST00000539972
H0YGX6 [Direct mapping]
Nuclear protein MDM1
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Predicted intracellular proteins
Show all
 121 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.