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Chromodomain helicase DNA binding protein 4 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Q14839 [Direct mapping] Chromodomain-helicase-DNA-binding protein 4
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008017 [microtubule binding] GO:0008026 [ATP-dependent helicase activity] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016581 [NuRD complex] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0031492 [nucleosomal DNA binding] GO:0032508 [DNA duplex unwinding] GO:0032993 [protein-DNA complex] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0051225 [spindle assembly] GO:0072553 [terminal button organization]
