Cell atlas - COPS7A - The Human Protein Atlas

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COPS7A

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	COPS7A
Gene description	COP9 signalosome subunit 7A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026915
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026915	A-431	Nucleoplasm
	HPA026915	U-2 OS	Nucleoplasm
	HPA026915	U-251 MG	Nucleoplasm
	HPA026915	U-251 MG	Cytosol

GENE INFORMATION
Gene name	COPS7A (HGNC Symbol)
Synonyms	CSN7A
Description	COP9 signalosome subunit 7A (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6723741 - 6731875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111652 (version 83.38)
Entrez gene	50813
UniProt	Q9UBW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBW8
Antibodypedia	COPS7A antibodies

PROTEIN BROWSER

COPS7A-001	COPS7A-002	COPS7A-003	COPS7A-004	COPS7A-006	COPS7A-015	COPS7A-022	COPS7A-024	COPS7A-027	COPS7A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COPS7A-001 ENSP00000438115 ENST00000543155	Q9UBW8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	275 aa 30.3 kDa	No	0
COPS7A-002 ENSP00000446039 ENST00000534947	Q9UBW8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	275 aa 30.3 kDa	No	0
COPS7A-003 ENSP00000438363 ENST00000534877	Q9UBW8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	275 aa 30.3 kDa	No	0
COPS7A-004 ENSP00000441852 ENST00000539735	Q9UBW8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	275 aa 30.3 kDa	No	0
COPS7A-006 ENSP00000229251 ENST00000229251	Q9UBW8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	275 aa 30.3 kDa	No	0
COPS7A-015 ENSP00000439547 ENST00000538410	F5H248 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	262 aa 29 kDa	No	0
COPS7A-022 ENSP00000440683 ENST00000538753	F5GYF7 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	213 aa 23.7 kDa	No	0
COPS7A-024 ENSP00000439949 ENST00000544725	F5H4U8 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	125 aa 13.7 kDa	No	0
COPS7A-027 ENSP00000442613 ENST00000541866	F5H7C6 [Direct mapping] COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	192 aa 21.3 kDa	No	0
COPS7A-201 ENSP00000487362 ENST00000626119	G3XAP1 [Direct mapping] COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), isoform CRA_b; COP9 signalosome complex subunit 7a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.