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ING4

CANCER ATLAS

Gene description

 Inhibitor of growth family, member 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057338

GENE INFORMATION

Gene name

 ING4 (HGNC Symbol)

Synonyms

 my036, p29ING4

Description

 Inhibitor of growth family, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6650280 - 6663148

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111653 (version 83.38)

Entrez gene

 51147

UniProt

 Q9UNL4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNL4

Antibodypedia

 ING4 antibodies

PROTEIN BROWSER
ING4-001
ING4-002
ING4-003
ING4-006
ING4-007
ING4-019
ING4-020
ING4-021
ING4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ING4-001
ENSP00000343396
ENST00000341550
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 248 aa
28.4 kDa 		No 0
ING4-002
ENSP00000380024
ENST00000396807
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 249 aa
28.5 kDa 		No 0
ING4-003
ENSP00000415903
ENST00000446105
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 245 aa
28.1 kDa 		No 0
ING4-006
ENSP00000473635
ENST00000467678
R4GNG1 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0008285 [negative regulation of cell proliferation]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 51 aa
5.7 kDa 		No 0
ING4-007
ENSP00000437198
ENST00000493873
E9PNE3 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.2 kDa 		No 0
ING4-019
ENSP00000414008
ENST00000423703
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 179 aa
20.5 kDa 		No 0
ING4-020
ENSP00000412705
ENST00000412586
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 246 aa
28.2 kDa 		No 0
ING4-021
ENSP00000397343
ENST00000444704
Q9UNL4 [Direct mapping]
Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
Show all
 225 aa
25.6 kDa 		No 0
ING4-201
ENSP00000480978
ENST00000619641
A4KYM5 [Direct mapping]
Inhibitor of growth family member 4 variant deltaEx3; Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0008285 [negative regulation of cell proliferation]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 51 aa
5.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.