Expression of USP5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ubiquitin specific peptidase 5 (isopeptidase T)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006756

GENE INFORMATION
Gene name	USP5 (HGNC Symbol)
Synonyms	IsoT
Description	Ubiquitin specific peptidase 5 (isopeptidase T) (HGNC Symbol)
Entrez gene summary	Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6852128 - 6866632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111667 (version 83.38)
Entrez gene	8078
UniProt	P45974 (UniProt - Evidence at protein level)
neXtProt	NX_P45974
Antibodypedia	USP5 antibodies

PROTEIN BROWSER

USP5-001	USP5-002	USP5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP5-001 ENSP00000229268 ENST00000229268	P45974 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008242 [omega peptidase activity] GO:0008270 [zinc ion binding] GO:0016579 [protein deubiquitination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] Show all	858 aa 95.8 kDa	No	0
USP5-002 ENSP00000373883 ENST00000389231	P45974 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008242 [omega peptidase activity] GO:0008270 [zinc ion binding] GO:0016579 [protein deubiquitination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] Show all	835 aa 93.3 kDa	No	0
USP5-003 ENSP00000444668 ENST00000542087	F5H571 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	137 aa 15.7 kDa	No	0