Cell atlas - USP5 - The Human Protein Atlas

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USP5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	USP5
Gene description	Ubiquitin specific peptidase 5 (isopeptidase T)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Mouse	Localized to the Nucleoplasm, Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006756
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006756	A-431	Nucleoplasm
	HPA006756	A-431	Cytosol
	HPA006756	U-2 OS	Nucleoplasm
	HPA006756	U-2 OS	Cytosol
	HPA006756	U-251 MG	Nucleoplasm
	HPA006756	U-251 MG	Cytosol

MOUSE CELLS

Main location

Nucleoplasm, Cytosol

Mouse gene

ENSMUSG00000038429 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA006756	NIH 3T3	Nucleoplasm
	HPA006756	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	USP5 (HGNC Symbol)
Synonyms	IsoT
Description	Ubiquitin specific peptidase 5 (isopeptidase T) (HGNC Symbol)
Entrez gene summary	Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6852128 - 6866632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111667 (version 83.38)
Entrez gene	8078
UniProt	P45974 (UniProt - Evidence at protein level)
neXtProt	NX_P45974
Antibodypedia	USP5 antibodies

PROTEIN BROWSER

USP5-001	USP5-002	USP5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP5-001 ENSP00000229268 ENST00000229268	P45974 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008242 [omega peptidase activity] GO:0008270 [zinc ion binding] GO:0016579 [protein deubiquitination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] Show all	858 aa 95.8 kDa	No	0
USP5-002 ENSP00000373883 ENST00000389231	P45974 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008242 [omega peptidase activity] GO:0008270 [zinc ion binding] GO:0016579 [protein deubiquitination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] Show all	835 aa 93.3 kDa	No	0
USP5-003 ENSP00000444668 ENST00000542087	F5H571 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	137 aa 15.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.