Expression of ATN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Atrophin 1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA031619

GENE INFORMATION
Gene name	ATN1 (HGNC Symbol)
Synonyms	B37, D12S755E, DRPLA
Description	Atrophin 1 (HGNC Symbol)
Entrez gene summary	Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6924463 - 6942321
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111676 (version 83.38)
Entrez gene	1822
UniProt	P54259 (UniProt - Evidence at protein level)
neXtProt	NX_P54259
Antibodypedia	ATN1 antibodies

PROTEIN BROWSER

ATN1-001	ATN1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATN1-001 ENSP00000379915 ENST00000396684	P54259 [Direct mapping] Atrophin-1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0016363 [nuclear matrix] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0048471 [perinuclear region of cytoplasm] GO:0051402 [neuron apoptotic process] Show all	1190 aa 125.4 kDa	No	0
ATN1-002 ENSP00000349076 ENST00000356654	P54259 [Direct mapping] Atrophin-1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0016363 [nuclear matrix] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0048471 [perinuclear region of cytoplasm] GO:0051402 [neuron apoptotic process] Show all	1190 aa 125.4 kDa	No	0