Expression of NANOG in cancer - Summary

CANCER ATLAS

Gene description

Nanog homeobox

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

CAB019380

GENE INFORMATION
Gene name	NANOG (HGNC Symbol)
Synonyms	FLJ12581, FLJ40451
Description	Nanog homeobox (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7787794 - 7799141
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111704 (version 83.38)
Entrez gene	79923
UniProt	Q9H9S0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H9S0
Antibodypedia	NANOG antibodies

PROTEIN BROWSER

NANOG-001	NANOG-002	NANOG-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NANOG-001 ENSP00000229307 ENST00000229307	Q9H9S0 [Direct mapping] Homeobox protein NANOG Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001714 [endodermal cell fate specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008283 [cell proliferation] GO:0010468 [regulation of gene expression] GO:0019827 [stem cell population maintenance] GO:0030154 [cell differentiation] GO:0035019 [somatic stem cell population maintenance] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	305 aa 34.6 kDa	No	0
NANOG-002 ENSP00000435288 ENST00000526286	Q9H9S0 [Direct mapping] Homeobox protein NANOG Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001714 [endodermal cell fate specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008283 [cell proliferation] GO:0010468 [regulation of gene expression] GO:0019827 [stem cell population maintenance] GO:0030154 [cell differentiation] GO:0035019 [somatic stem cell population maintenance] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	289 aa 32.8 kDa	No	0
NANOG-004 ENSP00000444434 ENST00000541267	F5GZI2 [Direct mapping] Homeobox protein NANOG Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	186 aa 21.2 kDa	No	0