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NANOG

GENERAL INFORMATION

Gene name

 NANOG

Gene description

 Nanog homeobox

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Not detected
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in testis cancer

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB019380
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 NANOG (HGNC Symbol)

Synonyms

 FLJ12581, FLJ40451

Description

 Nanog homeobox (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 7787794 - 7799141

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111704 (version 83.38)

Entrez gene

 79923

UniProt

 Q9H9S0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H9S0

Antibodypedia

 NANOG antibodies

PROTEIN BROWSER
NANOG-001
NANOG-002
NANOG-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NANOG-001
ENSP00000229307
ENST00000229307
Q9H9S0 [Direct mapping]
Homeobox protein NANOG
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001714 [endodermal cell fate specification]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 305 aa
34.6 kDa 		No 0
NANOG-002
ENSP00000435288
ENST00000526286
Q9H9S0 [Direct mapping]
Homeobox protein NANOG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001714 [endodermal cell fate specification]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 289 aa
32.8 kDa 		No 0
NANOG-004
ENSP00000444434
ENST00000541267
F5GZI2 [Direct mapping]
Homeobox protein NANOG
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 186 aa
21.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.