Cell atlas - PHC1 - The Human Protein Atlas

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PHC1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PHC1
Gene description	Polyhomeotic homolog 1 (Drosophila)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Group enriched (NTERA-2, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006973
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (NTERA-2, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006973	A-431	Nucleus
	HPA006973	U-2 OS	Nucleus
	HPA006973	U-251 MG	Nucleus

GENE INFORMATION
Gene name	PHC1 (HGNC Symbol)
Synonyms	EDR1, HPH1, RAE28
Description	Polyhomeotic homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8913896 - 8941467
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111752 (version 83.38)
Entrez gene	1911
UniProt	P78364 (UniProt - Evidence at protein level)
neXtProt	NX_P78364
Antibodypedia	PHC1 antibodies

PROTEIN BROWSER

PHC1-001	PHC1-002	PHC1-003	PHC1-006	PHC1-007	PHC1-008	PHC1-009	PHC1-010	PHC1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHC1-001 ENSP00000440674 ENST00000543824	P78364 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001739 [sex chromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0016574 [histone ubiquitination] GO:0016604 [nuclear body] GO:0016925 [protein sumoylation] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0071300 [cellular response to retinoic acid] Show all	1004 aa 105.5 kDa	No	0
PHC1-002 ENSP00000437659 ENST00000544916	P78364 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0016574 [histone ubiquitination] GO:0016925 [protein sumoylation] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1004 aa 105.5 kDa	No	0
PHC1-003 ENSP00000399194 ENST00000433083	J3KQH6 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] Show all	959 aa 100.5 kDa	No	0
PHC1-006 ENSP00000437654 ENST00000538657	F5H6F5 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.4 kDa	No	0
PHC1-007 ENSP00000445939 ENST00000541181	F5H0T9 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 16.6 kDa	No	0
PHC1-008 ENSP00000437645 ENST00000544539	F5H6F9 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		179 aa 19.1 kDa	No	0
PHC1-009 ENSP00000437459 ENST00000539063	F5H6P9 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 19.2 kDa	No	0
PHC1-010 ENSP00000446388 ENST00000542346	H0YH74 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 9.5 kDa	No	0
PHC1-012 ENSP00000443676 ENST00000537610	H0YGK7 [Direct mapping] Polyhomeotic-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 20.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.