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Searches

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Detectable

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PHC1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PHC1

Gene description

Polyhomeotic homolog 1 (Drosophila)

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Mixed
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression with additional cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA006973
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina010203040506070Tags Per Million

GENE INFORMATION

Gene name

PHC1 (HGNC Symbol)

Synonyms

EDR1, HPH1, RAE28

Description

Polyhomeotic homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

8913896 - 8941467

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111752 (version 83.38)

Entrez gene

1911

UniProt

P78364 (UniProt - Evidence at protein level)

neXtProt

NX_P78364

Antibodypedia

PHC1 antibodies

PROTEIN BROWSER

PHC1-001
PHC1-002
PHC1-003
PHC1-006
PHC1-007
PHC1-008
PHC1-009
PHC1-010
PHC1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHC1-001
ENSP00000440674
ENST00000543824
P78364 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001739 [sex chromatin]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0016574 [histone ubiquitination]
GO:0016604 [nuclear body]
GO:0016925 [protein sumoylation]
GO:0031519 [PcG protein complex]
GO:0035102 [PRC1 complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0071300 [cellular response to retinoic acid]
Show all
1004 aa
105.5 kDa
No 0
PHC1-002
ENSP00000437659
ENST00000544916
P78364 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0016574 [histone ubiquitination]
GO:0016925 [protein sumoylation]
GO:0031519 [PcG protein complex]
GO:0035102 [PRC1 complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
1004 aa
105.5 kDa
No 0
PHC1-003
ENSP00000399194
ENST00000433083
J3KQH6 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
Show all
959 aa
100.5 kDa
No 0
PHC1-006
ENSP00000437654
ENST00000538657
F5H6F5 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
172 aa
18.4 kDa
No 0
PHC1-007
ENSP00000445939
ENST00000541181
F5H0T9 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
158 aa
16.6 kDa
No 0
PHC1-008
ENSP00000437645
ENST00000544539
F5H6F9 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
179 aa
19.1 kDa
No 0
PHC1-009
ENSP00000437459
ENST00000539063
F5H6P9 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
183 aa
19.2 kDa
No 0
PHC1-010
ENSP00000446388
ENST00000542346
H0YH74 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
99 aa
9.5 kDa
No 0
PHC1-012
ENSP00000443676
ENST00000537610
H0YGK7 [Direct mapping]
Polyhomeotic-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
187 aa
20.4 kDa
No 0

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