Cell atlas - RFX4 - The Human Protein Atlas

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RFX4

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RFX4
Gene description	Regulatory factor X, 4 (influences HLA class II expression)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enriched (AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050527
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050527	AF22	Nucleus

GENE INFORMATION
Gene name	RFX4
Synonyms
Description	Regulatory factor X, 4 (influences HLA class II expression) (HGNC Symbol)
Entrez gene summary	This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	106582907 - 106762803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111783 (version 83.38)
Entrez gene	5992
UniProt	Q33E94 (UniProt - Evidence at protein level)
neXtProt	NX_Q33E94
Antibodypedia	RFX4 antibodies

PROTEIN BROWSER

RFX4-001	RFX4-002	RFX4-003	RFX4-004	RFX4-009	RFX4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFX4-001 ENSP00000229387 ENST00000229387	Q33E94 [Direct mapping] Transcription factor RFX4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0042384 [cilium assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	641 aa 72.6 kDa	No	0
RFX4-002 ENSP00000376585 ENST00000392842	Q33E94 [Direct mapping] Transcription factor RFX4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0042384 [cilium assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	735 aa 83.4 kDa	No	0
RFX4-003 ENSP00000350552 ENST00000357881	Q33E94 [Direct mapping] Transcription factor RFX4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0021516 [dorsal spinal cord development] GO:0021537 [telencephalon development] GO:0021696 [cerebellar cortex morphogenesis] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0030900 [forebrain development] GO:0030901 [midbrain development] GO:0042384 [cilium assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070613 [regulation of protein processing] Show all	744 aa 84.5 kDa	No	0
RFX4-004 ENSP00000473326 ENST00000539967	R4GMS3 [Direct mapping] Transcription factor RFX4 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0042384 [cilium assembly] Show all	145 aa 16.7 kDa	No	0
RFX4-009 ENSP00000447735 ENST00000549040	F8VZC4 [Direct mapping] Transcription factor RFX4 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0042384 [cilium assembly] Show all	59 aa 7 kDa	No	0
RFX4-010 ENSP00000448694 ENST00000551640	F8VRD4 [Direct mapping] Transcription factor RFX4 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning] GO:0042384 [cilium assembly] Show all	256 aa 29.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.