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RFX4

GENERAL INFORMATION

Gene name

 RFX4

Gene description

 Regulatory factor X, 4 (influences HLA class II expression)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, cerebral cortex)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in testis and cytoplasmic expression in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA050527
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 RFX4

Synonyms

Description

 Regulatory factor X, 4 (influences HLA class II expression) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 106582907 - 106762803

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111783 (version 83.38)

Entrez gene

 5992

UniProt

 Q33E94 (UniProt - Evidence at protein level)

neXtProt

 NX_Q33E94

Antibodypedia

 RFX4 antibodies

PROTEIN BROWSER
RFX4-001
RFX4-002
RFX4-003
RFX4-004
RFX4-009
RFX4-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RFX4-001
ENSP00000229387
ENST00000229387
Q33E94 [Direct mapping]
Transcription factor RFX4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0042384 [cilium assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 641 aa
72.6 kDa 		No 0
RFX4-002
ENSP00000376585
ENST00000392842
Q33E94 [Direct mapping]
Transcription factor RFX4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0042384 [cilium assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 735 aa
83.4 kDa 		No 0
RFX4-003
ENSP00000350552
ENST00000357881
Q33E94 [Direct mapping]
Transcription factor RFX4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021516 [dorsal spinal cord development]
GO:0021537 [telencephalon development]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0042384 [cilium assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070613 [regulation of protein processing]
Show all
 744 aa
84.5 kDa 		No 0
RFX4-004
ENSP00000473326
ENST00000539967
R4GMS3 [Direct mapping]
Transcription factor RFX4
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0042384 [cilium assembly]
Show all
 145 aa
16.7 kDa 		No 0
RFX4-009
ENSP00000447735
ENST00000549040
F8VZC4 [Direct mapping]
Transcription factor RFX4
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0042384 [cilium assembly]
Show all
 59 aa
7 kDa 		No 0
RFX4-010
ENSP00000448694
ENST00000551640
F8VRD4 [Direct mapping]
Transcription factor RFX4
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0042384 [cilium assembly]
Show all
 256 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.