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MAK

CANCER ATLAS

Gene description

 Male germ cell-associated kinase

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039092

GENE INFORMATION

Gene name

 MAK (HGNC Symbol)

Synonyms

 dJ417M14.2, RP62

Description

 Male germ cell-associated kinase (HGNC Symbol)

Entrez gene summary

 The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 6

Cytoband

 p24.2

Chromosome location (bp)

 10762723 - 10838555

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111837 (version 83.38)

Entrez gene

 4117

UniProt

 P20794 (UniProt - Evidence at protein level)

neXtProt

 NX_P20794

Antibodypedia

 MAK antibodies

PROTEIN BROWSER
MAK-001
MAK-002
MAK-201
MAK-202
MAK-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAK-001
ENSP00000313021
ENST00000313243
P20794 [Direct mapping]
Serine/threonine-protein kinase MAK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003713 [transcription coactivator activity]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0045494 [photoreceptor cell maintenance]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0072686 [mitotic spindle]
Show all
 623 aa
70.6 kDa 		No 0
MAK-002
ENSP00000476067
ENST00000474039
P20794 [Direct mapping]
Serine/threonine-protein kinase MAK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003713 [transcription coactivator activity]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0045494 [photoreceptor cell maintenance]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0072686 [mitotic spindle]
Show all
 623 aa
70.6 kDa 		No 0
MAK-201
ENSP00000346484
ENST00000354489
P20794 [Direct mapping]
Serine/threonine-protein kinase MAK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003713 [transcription coactivator activity]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0045494 [photoreceptor cell maintenance]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0072686 [mitotic spindle]
Show all
 648 aa
73.5 kDa 		No 0
MAK-202
ENSP00000442221
ENST00000536370
P20794 [Direct mapping]
Serine/threonine-protein kinase MAK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003713 [transcription coactivator activity]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0045494 [photoreceptor cell maintenance]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0072686 [mitotic spindle]
Show all
 583 aa
66.3 kDa 		No 0
MAK-203
ENSP00000442250
ENST00000538030
Q8IXN4 [Direct mapping]
MAK protein; Serine/threonine-protein kinase MAK
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 457 aa
52.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.