Tissue expression of MAK - Summary - The Human Protein Atlas

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MAK

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAK
Gene description	Male germ cell-associated kinase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, parathyroid gland, fallopian tube)
GTEx:	Tissue enriched (testis)
FANTOM5:	Group enriched (retina, testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA039092
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, parathyroid gland, fallopian tube)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, testis)

GENE INFORMATION
Gene name	MAK (HGNC Symbol)
Synonyms	dJ417M14.2, RP62
Description	Male germ cell-associated kinase (HGNC Symbol)
Entrez gene summary	The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Chromosome	6
Cytoband	p24.2
Chromosome location (bp)	10762723 - 10838555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111837 (version 83.38)
Entrez gene	4117
UniProt	P20794 (UniProt - Evidence at protein level)
neXtProt	NX_P20794
Antibodypedia	MAK antibodies

PROTEIN BROWSER

MAK-001	MAK-002	MAK-201	MAK-202	MAK-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAK-001 ENSP00000313021 ENST00000313243	P20794 [Direct mapping] Serine/threonine-protein kinase MAK Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0030496 [midbody] GO:0045494 [photoreceptor cell maintenance] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0072686 [mitotic spindle] Show all	623 aa 70.6 kDa	No	0
MAK-002 ENSP00000476067 ENST00000474039	P20794 [Direct mapping] Serine/threonine-protein kinase MAK Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0030496 [midbody] GO:0045494 [photoreceptor cell maintenance] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0072686 [mitotic spindle] Show all	623 aa 70.6 kDa	No	0
MAK-201 ENSP00000346484 ENST00000354489	P20794 [Direct mapping] Serine/threonine-protein kinase MAK Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0030496 [midbody] GO:0045494 [photoreceptor cell maintenance] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0072686 [mitotic spindle] Show all	648 aa 73.5 kDa	No	0
MAK-202 ENSP00000442221 ENST00000536370	P20794 [Direct mapping] Serine/threonine-protein kinase MAK Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0030496 [midbody] GO:0045494 [photoreceptor cell maintenance] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0072686 [mitotic spindle] Show all	583 aa 66.3 kDa	No	0
MAK-203 ENSP00000442250 ENST00000538030	Q8IXN4 [Direct mapping] MAK protein; Serine/threonine-protein kinase MAK Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	457 aa 52.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.