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GMDS

CANCER ATLAS

Gene description

 GDP-mannose 4,6-dehydratase

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031528

GENE INFORMATION

Gene name

 GMDS (HGNC Symbol)

Synonyms

 GMD, SDR3E1

Description

 GDP-mannose 4,6-dehydratase (HGNC Symbol)

Entrez gene summary

 GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]

Chromosome

 6

Cytoband

 p25.3

Chromosome location (bp)

 1623806 - 2245692

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112699 (version 83.38)

Entrez gene

 2762

UniProt

 O60547 (UniProt - Evidence at protein level)

neXtProt

 NX_O60547

Antibodypedia

 GMDS antibodies

PROTEIN BROWSER
GMDS-001
GMDS-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMDS-001
ENSP00000370194
ENST00000380815
O60547 [Direct mapping]
GDP-mannose 4,6 dehydratase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007219 [Notch signaling pathway]
GO:0008446 [GDP-mannose 4,6-dehydratase activity]
GO:0019673 [GDP-mannose metabolic process]
GO:0042351 ['de novo' GDP-L-fucose biosynthetic process]
GO:0050662 [coenzyme binding]
GO:0070062 [extracellular exosome]
GO:0070401 [NADP+ binding]
Show all
 372 aa
41.9 kDa 		No 0
GMDS-007
ENSP00000436726
ENST00000530927
O60547 [Direct mapping]
GDP-mannose 4,6 dehydratase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007219 [Notch signaling pathway]
GO:0008446 [GDP-mannose 4,6-dehydratase activity]
GO:0019673 [GDP-mannose metabolic process]
GO:0042351 ['de novo' GDP-L-fucose biosynthetic process]
GO:0050662 [coenzyme binding]
GO:0070062 [extracellular exosome]
GO:0070401 [NADP+ binding]
Show all
 342 aa
39.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.