Cell atlas - GMDS - The Human Protein Atlas

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GMDS

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GMDS
Gene description	GDP-mannose 4,6-dehydratase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GMDS (HGNC Symbol)
Synonyms	GMD, SDR3E1
Description	GDP-mannose 4,6-dehydratase (HGNC Symbol)
Entrez gene summary	GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Chromosome	6
Cytoband	p25.3
Chromosome location (bp)	1623806 - 2245692
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112699 (version 83.38)
Entrez gene	2762
UniProt	O60547 (UniProt - Evidence at protein level)
neXtProt	NX_O60547
Antibodypedia	GMDS antibodies

PROTEIN BROWSER

GMDS-001	GMDS-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMDS-001 ENSP00000370194 ENST00000380815	O60547 [Direct mapping] GDP-mannose 4,6 dehydratase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007219 [Notch signaling pathway] GO:0008446 [GDP-mannose 4,6-dehydratase activity] GO:0019673 [GDP-mannose metabolic process] GO:0042351 ['de novo' GDP-L-fucose biosynthetic process] GO:0050662 [coenzyme binding] GO:0070062 [extracellular exosome] GO:0070401 [NADP+ binding] Show all	372 aa 41.9 kDa	No	0
GMDS-007 ENSP00000436726 ENST00000530927	O60547 [Direct mapping] GDP-mannose 4,6 dehydratase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007219 [Notch signaling pathway] GO:0008446 [GDP-mannose 4,6-dehydratase activity] GO:0019673 [GDP-mannose metabolic process] GO:0042351 ['de novo' GDP-L-fucose biosynthetic process] GO:0050662 [coenzyme binding] GO:0070062 [extracellular exosome] GO:0070401 [NADP+ binding] Show all	342 aa 39.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.