Cell atlas - TTK - The Human Protein Atlas

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TTK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	TTK
Gene description	TTK protein kinase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB010166
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & cytosol.

Main location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010166	A-431	Nucleoli
	CAB010166	A-431	Cytosol
	CAB010166	U-2 OS	Nucleoli
	CAB010166	U-2 OS	Cytosol
	CAB010166	U-251 MG	Nucleoli
	CAB010166	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TTK (HGNC Symbol)
Synonyms	CT96, MPH1, MPS1, MPS1L1
Description	TTK protein kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Chromosome	6
Cytoband	q14.1
Chromosome location (bp)	80003887 - 80042527
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112742 (version 83.38)
Entrez gene	7272
UniProt	P33981 (UniProt - Evidence at protein level)
neXtProt	NX_P33981
Antibodypedia	TTK antibodies

PROTEIN BROWSER

TTK-001	TTK-002	TTK-003	TTK-004	TTK-005	TTK-006	TTK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTK-001 ENSP00000358813 ENST00000369798	P33981 [Direct mapping] Dual specificity protein kinase TTK Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005819 [spindle] GO:0006468 [protein phosphorylation] GO:0007051 [spindle organization] GO:0007052 [mitotic spindle organization] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008284 [positive regulation of cell proliferation] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0051304 [chromosome separation] Show all	857 aa 97.1 kDa	No	0
TTK-002 ENSP00000230510 ENST00000230510	P33981 [Direct mapping] Dual specificity protein kinase TTK Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005819 [spindle] GO:0006468 [protein phosphorylation] GO:0007051 [spindle organization] GO:0007052 [mitotic spindle organization] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008284 [positive regulation of cell proliferation] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0051304 [chromosome separation] Show all	856 aa 96.9 kDa	No	0
TTK-003 ENSP00000422936 ENST00000509894	P33981 [Direct mapping] Dual specificity protein kinase TTK Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005819 [spindle] GO:0006468 [protein phosphorylation] GO:0007051 [spindle organization] GO:0007052 [mitotic spindle organization] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008284 [positive regulation of cell proliferation] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0051304 [chromosome separation] Show all	856 aa 96.9 kDa	No	0
TTK-004 ENSP00000421636 ENST00000511260	D6REX1 [Direct mapping] Dual-specificity protein kinase TTK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0007093 [mitotic cell cycle checkpoint] GO:0051304 [chromosome separation] Show all	150 aa 17.1 kDa	No	0
TTK-005 ENSP00000424851 ENST00000502580	D6RF82 [Direct mapping] Dual-specificity protein kinase TTK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0007093 [mitotic cell cycle checkpoint] GO:0051304 [chromosome separation] Show all	139 aa 15.8 kDa	No	0
TTK-006 ENSP00000427483 ENST00000504040	D6RIC6 [Direct mapping] Dual-specificity protein kinase TTK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0007093 [mitotic cell cycle checkpoint] GO:0051304 [chromosome separation] Show all	176 aa 19.9 kDa	No	0
TTK-201 ENSP00000487202 ENST00000627129	D6RFY1 [Direct mapping] Dual-specificity protein kinase TTK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0007093 [mitotic cell cycle checkpoint] GO:0051304 [chromosome separation] Show all	79 aa 9.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.