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TTK

GENERAL INFORMATION

Gene name

 TTK

Gene description

 TTK protein kinase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different cell types, most abundant in highly proliferative cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending retesting.

Reliability score

 Approved based on 1 antibody.
CAB013229
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 TTK (HGNC Symbol)

Synonyms

 CT96, MPH1, MPS1, MPS1L1

Description

 TTK protein kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 80003887 - 80042527

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112742 (version 83.38)

Entrez gene

 7272

UniProt

 P33981 (UniProt - Evidence at protein level)

neXtProt

 NX_P33981

Antibodypedia

 TTK antibodies

PROTEIN BROWSER
TTK-001
TTK-002
TTK-003
TTK-004
TTK-005
TTK-006
TTK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TTK-001
ENSP00000358813
ENST00000369798
P33981 [Direct mapping]
Dual specificity protein kinase TTK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005819 [spindle]
GO:0006468 [protein phosphorylation]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008284 [positive regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0051304 [chromosome separation]
Show all
 857 aa
97.1 kDa 		No 0
TTK-002
ENSP00000230510
ENST00000230510
P33981 [Direct mapping]
Dual specificity protein kinase TTK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005819 [spindle]
GO:0006468 [protein phosphorylation]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008284 [positive regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0051304 [chromosome separation]
Show all
 856 aa
96.9 kDa 		No 0
TTK-003
ENSP00000422936
ENST00000509894
P33981 [Direct mapping]
Dual specificity protein kinase TTK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005819 [spindle]
GO:0006468 [protein phosphorylation]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008284 [positive regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0051304 [chromosome separation]
Show all
 856 aa
96.9 kDa 		No 0
TTK-004
ENSP00000421636
ENST00000511260
D6REX1 [Direct mapping]
Dual-specificity protein kinase TTK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0051304 [chromosome separation]
Show all
 150 aa
17.1 kDa 		No 0
TTK-005
ENSP00000424851
ENST00000502580
D6RF82 [Direct mapping]
Dual-specificity protein kinase TTK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0051304 [chromosome separation]
Show all
 139 aa
15.8 kDa 		No 0
TTK-006
ENSP00000427483
ENST00000504040
D6RIC6 [Direct mapping]
Dual-specificity protein kinase TTK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0051304 [chromosome separation]
Show all
 176 aa
19.9 kDa 		No 0
TTK-201
ENSP00000487202
ENST00000627129
D6RFY1 [Direct mapping]
Dual-specificity protein kinase TTK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0051304 [chromosome separation]
Show all
 79 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.