Expression of SLC29A1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 29 (equilibrative nucleoside transporter), member 1

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012384

GENE INFORMATION
Gene name	SLC29A1 (HGNC Symbol)
Synonyms	ENT1
Description	Solute carrier family 29 (equilibrative nucleoside transporter), member 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44219505 - 44234151
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112759 (version 83.38)
Entrez gene	2030
UniProt	Q99808 (UniProt - Evidence at protein level)
neXtProt	NX_Q99808
Antibodypedia	SLC29A1 antibodies

PROTEIN BROWSER

SLC29A1-002	SLC29A1-003	SLC29A1-004	SLC29A1-005	SLC29A1-006	SLC29A1-007	SLC29A1-008	SLC29A1-201	SLC29A1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC29A1-002 ENSP00000392668 ENST00000427851	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-003 ENSP00000360820 ENST00000371755	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-004 ENSP00000360805 ENST00000371740	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-005 ENSP00000360773 ENST00000371708	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-006 ENSP00000360796 ENST00000371731	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-007 ENSP00000360789 ENST00000371724	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-008 ENSP00000360778 ENST00000371713	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-201 ENSP00000377424 ENST00000393841	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0007595 [lactation] GO:0015858 [nucleoside transport] GO:0015862 [uridine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030431 [sleep] GO:0055085 [transmembrane transport] GO:0060079 [excitatory postsynaptic potential] GO:0071333 [cellular response to glucose stimulus] GO:0071456 [cellular response to hypoxia] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9
SLC29A1-202 ENSP00000377427 ENST00000393844	Q99808 [Direct mapping] Equilibrative nucleoside transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.2 kDa	No	>9