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SLC29A1

GENERAL INFORMATION

Gene name

 SLC29A1

Gene description

 Solute carrier family 29 (equilibrative nucleoside transporter), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA012384
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC29A1 (HGNC Symbol)

Synonyms

 ENT1

Description

 Solute carrier family 29 (equilibrative nucleoside transporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44219505 - 44234151

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112759 (version 83.38)

Entrez gene

 2030

UniProt

 Q99808 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99808

Antibodypedia

 SLC29A1 antibodies

PROTEIN BROWSER
SLC29A1-002
SLC29A1-003
SLC29A1-004
SLC29A1-005
SLC29A1-006
SLC29A1-007
SLC29A1-008
SLC29A1-201
SLC29A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC29A1-002
ENSP00000392668
ENST00000427851
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-003
ENSP00000360820
ENST00000371755
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-004
ENSP00000360805
ENST00000371740
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-005
ENSP00000360773
ENST00000371708
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-006
ENSP00000360796
ENST00000371731
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-007
ENSP00000360789
ENST00000371724
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-008
ENSP00000360778
ENST00000371713
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-201
ENSP00000377424
ENST00000393841
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0007595 [lactation]
GO:0015858 [nucleoside transport]
GO:0015862 [uridine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030431 [sleep]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0071333 [cellular response to glucose stimulus]
GO:0071456 [cellular response to hypoxia]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9
SLC29A1-202
ENSP00000377427
ENST00000393844
Q99808 [Direct mapping]
Equilibrative nucleoside transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005337 [nucleoside transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006810 [transport]
GO:0015858 [nucleoside transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0055085 [transmembrane transport]
GO:1901642 [nucleoside transmembrane transport]
Show all
 456 aa
50.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.