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ERBB2IP

CANCER ATLAS

Gene description

 Erbb2 interacting protein

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048606

GENE INFORMATION

Gene name

 ERBB2IP (HGNC Symbol)

Synonyms

 ERBIN, LAP2

Description

 Erbb2 interacting protein (HGNC Symbol)

Entrez gene summary

 This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 65926475 - 66082549

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112851 (version 83.38)

Entrez gene

 55914

UniProt

 Q96RT1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RT1

Antibodypedia

 ERBB2IP antibodies

PROTEIN BROWSER
ERBB2IP-001
ERBB2IP-002
ERBB2IP-003
ERBB2IP-004
ERBB2IP-005
ERBB2IP-006
ERBB2IP-007
ERBB2IP-013
ERBB2IP-014
ERBB2IP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERBB2IP-001
ENSP00000370330
ENST00000380943
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1371 aa
153.9 kDa 		No 0
ERBB2IP-002
ENSP00000284037
ENST00000284037
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1412 aa
158.3 kDa 		No 0
ERBB2IP-003
ENSP00000370325
ENST00000380938
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1346 aa
151.3 kDa 		No 0
ERBB2IP-004
ENSP00000426632
ENST00000506030
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071638 [negative regulation of monocyte chemotactic protein-1 production]
Show all
 1419 aa
159 kDa 		No 0
ERBB2IP-005
ENSP00000397833
ENST00000416865
B4DIP2 [Direct mapping]
Protein LAP2; cDNA FLJ58745, highly similar to Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 610 aa
68.6 kDa 		No 0
ERBB2IP-006
ENSP00000422766
ENST00000511297
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1367 aa
153.5 kDa 		No 0
ERBB2IP-007
ENSP00000422015
ENST00000508515
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1302 aa
146.1 kDa 		No 0
ERBB2IP-013
ENSP00000425728
ENST00000511671
H0YA04 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 197 aa
21.6 kDa 		No 0
ERBB2IP-014
ENSP00000423959
ENST00000512354
H0Y9E8 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 158 aa
17.3 kDa 		No 0
ERBB2IP-201
ENSP00000370322
ENST00000380935
Q96RT1 [Direct mapping]
Protein LAP2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030056 [hemidesmosome]
GO:0031965 [nuclear membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045175 [basal protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 1302 aa
146.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.