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C7

GENERAL INFORMATION

Gene name

 C7

Gene description

 Complement component 7

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression

 Secreted positivity in a majority of tissues including adrenal gland and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA001465
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)

GENE INFORMATION

Gene name

 C7

Synonyms

Description

 Complement component 7 (HGNC Symbol)

Entrez gene summary

 C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p13.1

Chromosome location (bp)

 40909252 - 40982939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112936 (version 83.38)

Entrez gene

 730

UniProt

 P10643 (UniProt - Evidence at protein level)

neXtProt

 NX_P10643

Antibodypedia

 C7 antibodies

PROTEIN BROWSER
C7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C7-001
ENSP00000322061
ENST00000313164
P10643 [Direct mapping]
Complement component C7
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005579 [membrane attack complex]
GO:0006956 [complement activation]
GO:0006957 [complement activation, alternative pathway]
GO:0006958 [complement activation, classical pathway]
GO:0019835 [cytolysis]
GO:0030449 [regulation of complement activation]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
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 843 aa
93.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.