Moderate to strong cytoplasmic positivity was observed in hepatocellular carcinomas and several cases of endometrial and renal cancers. Few cases of pancreatic cancers and renal carcinoma showed moderate to strong luminal membranous and cytoplasmic staining. Most remaining cancer tissues were negative.
GHR (HGNC Symbol)
Growth hormone receptor (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]