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Gene name

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Subclass

Chromosome

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In atlas

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Reliability

Reliability

Validation

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Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

Column

 
 
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GHR
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GHR

Gene description

Growth hormone receptor

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (liver, adipose tissue)
GTEx:Group enriched (adipose tissue, liver, breast, skeletal muscle)
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Highly abundant cytoplasmic expression mainly in hepatocytes and membranous expression in renal tubular cells. Also expressed in the cell membrane in most glandular epithelia.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA045339
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, liver, breast, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

GHR (HGNC Symbol)

Synonyms

GHBP

Description

Growth hormone receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Chromosome

5

Cytoband

Chromosome location (bp)

42423777 - 42721878

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112964 (version 83.38)

Entrez gene

2690

UniProt

P10912 (UniProt - Evidence at protein level)

neXtProt

NX_P10912

Antibodypedia

GHR antibodies

PROTEIN BROWSER

GHR-001
GHR-201
GHR-202
GHR-203
GHR-204
GHR-205
GHR-206
GHR-207
GHR-208

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GHR-001
ENSP00000230882
ENST00000230882
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-201
ENSP00000350335
ENST00000357703
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
616 aa
69.2 kDa
Yes 1
GHR-202
ENSP00000442206
ENST00000537449
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-203
ENSP00000478332
ENST00000612382
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-204
ENSP00000479846
ENST00000612626
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-205
ENSP00000478291
ENST00000615111
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-206
ENSP00000482373
ENST00000618088
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
638 aa
71.5 kDa
Yes 1
GHR-207
ENSP00000483403
ENST00000620156
A0A087X0H5 [Direct mapping]
Growth hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004896 [cytokine receptor activity]
GO:0004903 [growth hormone receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0009725 [response to hormone]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019898 [extrinsic component of membrane]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0032094 [response to food]
GO:0032869 [cellular response to insulin stimulus]
GO:0034097 [response to cytokine]
GO:0042169 [SH2 domain binding]
GO:0042976 [activation of Janus kinase activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043025 [neuronal cell body]
GO:0043278 [response to morphine]
GO:0043434 [response to peptide hormone]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0051384 [response to glucocorticoid]
GO:0060351 [cartilage development involved in endochondral bone morphogenesis]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:1901215 [negative regulation of neuron death]
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645 aa
72.2 kDa
Yes 1
GHR-208
ENSP00000483926
ENST00000622294
A0A087X162 [Direct mapping]
Growth hormone receptor
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
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295 aa
34 kDa
Yes 1

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