Expression of SLC4A9 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 4, sodium bicarbonate cotransporter, member 9

Protein class

Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051307

GENE INFORMATION
Gene name	SLC4A9 (HGNC Symbol)
Synonyms	AE4
Description	Solute carrier family 4, sodium bicarbonate cotransporter, member 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140360202 - 140375143
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000113073 (version 83.38)
Entrez gene	83697
UniProt	Q96Q91 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96Q91
Antibodypedia	SLC4A9 antibodies

PROTEIN BROWSER

SLC4A9-001	SLC4A9-002	SLC4A9-003	SLC4A9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC4A9-001 ENSP00000424424 ENST00000506757	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	959 aa 105.7 kDa	No	>9
SLC4A9-002 ENSP00000427661 ENST00000507527	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	983 aa 108.2 kDa	No	>9
SLC4A9-003 ENSP00000422855 ENST00000506545	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	896 aa 98.9 kDa	No	>9
SLC4A9-004 ENSP00000410056 ENST00000432095	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	945 aa 104.1 kDa	No	>9