Tissue expression of SLC4A9 - Summary - The Human Protein Atlas

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SLC4A9

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC4A9
Gene description	Solute carrier family 4, sodium bicarbonate cotransporter, member 9
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (kidney)
GTEx:	Tissue enriched (kidney)
FANTOM5:	Tissue enriched (kidney)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA051307
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION
Gene name	SLC4A9 (HGNC Symbol)
Synonyms	AE4
Description	Solute carrier family 4, sodium bicarbonate cotransporter, member 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140360202 - 140375143
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000113073 (version 83.38)
Entrez gene	83697
UniProt	Q96Q91 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96Q91
Antibodypedia	SLC4A9 antibodies

PROTEIN BROWSER

SLC4A9-001	SLC4A9-002	SLC4A9-003	SLC4A9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC4A9-001 ENSP00000424424 ENST00000506757	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	959 aa 105.7 kDa	No	>9
SLC4A9-002 ENSP00000427661 ENST00000507527	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	983 aa 108.2 kDa	No	>9
SLC4A9-003 ENSP00000422855 ENST00000506545	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	896 aa 98.9 kDa	No	>9
SLC4A9-004 ENSP00000410056 ENST00000432095	Q96Q91 [Direct mapping] Anion exchange protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	945 aa 104.1 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.