Expression of APBB3 in cancer - Summary

CANCER ATLAS

Gene description

Amyloid beta (A4) precursor protein-binding, family B, member 3

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA005571

GENE INFORMATION
Gene name	APBB3 (HGNC Symbol)
Synonyms	FE65L2
Description	Amyloid beta (A4) precursor protein-binding, family B, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140558268 - 140593752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113108 (version 83.38)
Entrez gene	10307
UniProt	O95704 (UniProt - Evidence at protein level)
neXtProt	NX_O95704
Antibodypedia	APBB3 antibodies

PROTEIN BROWSER

APBB3-001	APBB3-002	APBB3-003	APBB3-011	APBB3-012	APBB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APBB3-001 ENSP00000349177 ENST00000356738	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	491 aa 53 kDa	No	0
APBB3-002 ENSP00000346378 ENST00000354402	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	493 aa 53.2 kDa	No	0
APBB3-003 ENSP00000350171 ENST00000357560	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	486 aa 52.6 kDa	No	0
APBB3-011 ENSP00000402591 ENST00000412920	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	484 aa 52.3 kDa	No	0
APBB3-012 ENSP00000424317 ENST00000511201	D6RBA1 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	337 aa 36.9 kDa	No	0
APBB3-201 ENSP00000351389 ENST00000358580	E7EX91 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	339 aa 37.2 kDa	No	0