Cell atlas - APBB3 - The Human Protein Atlas

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APBB3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	APBB3
Gene description	Amyloid beta (A4) precursor protein-binding, family B, member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & actin filaments.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA005571
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & actin filaments.

Main location

Actin filaments (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005571	A-431	Actin filaments
	HPA005571	A-431	Cytosol
	HPA005571	U-2 OS	Actin filaments
	HPA005571	U-2 OS	Cytosol
	HPA005571	U-251 MG	Actin filaments
	HPA005571	U-251 MG	Cytosol

GENE INFORMATION
Gene name	APBB3 (HGNC Symbol)
Synonyms	FE65L2
Description	Amyloid beta (A4) precursor protein-binding, family B, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140558268 - 140593752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113108 (version 83.38)
Entrez gene	10307
UniProt	O95704 (UniProt - Evidence at protein level)
neXtProt	NX_O95704
Antibodypedia	APBB3 antibodies

PROTEIN BROWSER

APBB3-001	APBB3-002	APBB3-003	APBB3-011	APBB3-012	APBB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APBB3-001 ENSP00000349177 ENST00000356738	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	491 aa 53 kDa	No	0
APBB3-002 ENSP00000346378 ENST00000354402	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	493 aa 53.2 kDa	No	0
APBB3-003 ENSP00000350171 ENST00000357560	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	486 aa 52.6 kDa	No	0
APBB3-011 ENSP00000402591 ENST00000412920	O95704 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	484 aa 52.3 kDa	No	0
APBB3-012 ENSP00000424317 ENST00000511201	D6RBA1 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	337 aa 36.9 kDa	No	0
APBB3-201 ENSP00000351389 ENST00000358580	E7EX91 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 3 Show all	Predicted intracellular proteins Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0015629 [actin cytoskeleton] Show all	339 aa 37.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.