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ARSB

GENERAL INFORMATION

Gene name

 ARSB

Gene description

 Arylsulfatase B

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression often with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA037770 , HPA037771
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARSB

Synonyms

Description

 Arylsulfatase B (HGNC Symbol)

Entrez gene summary

 Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 78777209 - 78986087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113273 (version 83.38)

Entrez gene

 411

UniProt

 P15848 (UniProt - Evidence at protein level)

neXtProt

 NX_P15848

Antibodypedia

 ARSB antibodies

PROTEIN BROWSER
ARSB-001
ARSB-002
ARSB-003
ARSB-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARSB-001
ENSP00000264914
ENST00000264914
P15848 [Direct mapping]
Arylsulfatase B
A0A024RAJ9 [Target identity:100%; Query identity:100%]
Arylsulfatase B, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003943 [N-acetylgalactosamine-4-sulfatase activity]
GO:0004065 [arylsulfatase activity]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006914 [autophagy]
GO:0007040 [lysosome organization]
GO:0007041 [lysosomal transport]
GO:0007417 [central nervous system development]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009268 [response to pH]
GO:0009986 [cell surface]
GO:0010632 [regulation of epithelial cell migration]
GO:0010976 [positive regulation of neuron projection development]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0043627 [response to estrogen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051597 [response to methylmercury]
GO:0061580 [colon epithelial cell migration]
GO:0070062 [extracellular exosome]
Show all
 533 aa
59.7 kDa 		Yes 0
ARSB-002
ENSP00000379455
ENST00000396151
P15848 [Direct mapping]
Arylsulfatase B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003943 [N-acetylgalactosamine-4-sulfatase activity]
GO:0004065 [arylsulfatase activity]
GO:0005764 [lysosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0007040 [lysosome organization]
GO:0007041 [lysosomal transport]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009986 [cell surface]
GO:0010632 [regulation of epithelial cell migration]
GO:0010976 [positive regulation of neuron projection development]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0061580 [colon epithelial cell migration]
GO:0070062 [extracellular exosome]
Show all
 413 aa
46 kDa 		Yes 0
ARSB-003
ENSP00000428611
ENST00000521117
E5RHC4 [Direct mapping]
Arylsulfatase B
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 45 aa
4.5 kDa 		Yes 0
ARSB-006
ENSP00000456339
ENST00000565165
P15848 [Direct mapping]
Arylsulfatase B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003943 [N-acetylgalactosamine-4-sulfatase activity]
GO:0004065 [arylsulfatase activity]
GO:0005764 [lysosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0007040 [lysosome organization]
GO:0007041 [lysosomal transport]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009986 [cell surface]
GO:0010632 [regulation of epithelial cell migration]
GO:0010976 [positive regulation of neuron projection development]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0061580 [colon epithelial cell migration]
GO:0070062 [extracellular exosome]
Show all
 413 aa
46 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.