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TARS

CANCER ATLAS

Gene description

 Threonyl-tRNA synthetase

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037425

GENE INFORMATION

Gene name

 TARS

Synonyms

Description

 Threonyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p13.3

Chromosome location (bp)

 33440696 - 33469539

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113407 (version 83.38)

Entrez gene

 6897

UniProt

 P26639 (UniProt - Evidence at protein level)

neXtProt

 NX_P26639

Antibodypedia

 TARS antibodies

PROTEIN BROWSER
TARS-001
TARS-002
TARS-004
TARS-007
TARS-008
TARS-201
TARS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TARS-001
ENSP00000265112
ENST00000265112
P26639 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004829 [threonine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006435 [threonyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0042803 [protein homodimerization activity]
GO:0043039 [tRNA aminoacylation]
GO:0070062 [extracellular exosome]
Show all
 723 aa
83.4 kDa 		No 0
TARS-002
ENSP00000424387
ENST00000502553
P26639 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004829 [threonine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006435 [threonyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0042803 [protein homodimerization activity]
GO:0043039 [tRNA aminoacylation]
GO:0070062 [extracellular exosome]
Show all
 723 aa
83.4 kDa 		No 0
TARS-004
ENSP00000387710
ENST00000455217
P26639 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004829 [threonine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006435 [threonyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0042803 [protein homodimerization activity]
GO:0043039 [tRNA aminoacylation]
GO:0070062 [extracellular exosome]
Show all
 756 aa
86.9 kDa 		No 0
TARS-007
ENSP00000422130
ENST00000514259
D6R9F8 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0015629 [actin cytoskeleton]
Show all
 129 aa
14.1 kDa 		No 0
TARS-008
ENSP00000422598
ENST00000506040
D6RBR8 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 50 aa
5.6 kDa 		No 0
TARS-201
ENSP00000486893
ENST00000626210
D6RCS6 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 66 aa
6.9 kDa 		No 0
TARS-202
ENSP00000486068
ENST00000627006
D6RHV7 [Direct mapping]
Threonine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.