Cell atlas - TARS - The Human Protein Atlas

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TARS

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	TARS
Gene description	Threonyl-tRNA synthetase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Actin filaments (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA037425
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the actin filaments.

Main location

Cytosol (supported)

Additional location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037425	A-431	Actin filaments
	HPA037425	A-431	Cytosol
	HPA037425	U-2 OS	Actin filaments
	HPA037425	U-2 OS	Cytosol
	HPA037425	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TARS
Synonyms
Description	Threonyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p13.3
Chromosome location (bp)	33440696 - 33469539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113407 (version 83.38)
Entrez gene	6897
UniProt	P26639 (UniProt - Evidence at protein level)
neXtProt	NX_P26639
Antibodypedia	TARS antibodies

PROTEIN BROWSER

TARS-001	TARS-002	TARS-004	TARS-007	TARS-008	TARS-201	TARS-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TARS-001 ENSP00000265112 ENST00000265112	P26639 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0015629 [actin cytoskeleton] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0042803 [protein homodimerization activity] GO:0043039 [tRNA aminoacylation] GO:0070062 [extracellular exosome] Show all	723 aa 83.4 kDa	No	0
TARS-002 ENSP00000424387 ENST00000502553	P26639 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0015629 [actin cytoskeleton] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0042803 [protein homodimerization activity] GO:0043039 [tRNA aminoacylation] GO:0070062 [extracellular exosome] Show all	723 aa 83.4 kDa	No	0
TARS-004 ENSP00000387710 ENST00000455217	P26639 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0015629 [actin cytoskeleton] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0042803 [protein homodimerization activity] GO:0043039 [tRNA aminoacylation] GO:0070062 [extracellular exosome] Show all	756 aa 86.9 kDa	No	0
TARS-007 ENSP00000422130 ENST00000514259	D6R9F8 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0015629 [actin cytoskeleton] Show all	129 aa 14.1 kDa	No	0
TARS-008 ENSP00000422598 ENST00000506040	D6RBR8 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.6 kDa	No	0
TARS-201 ENSP00000486893 ENST00000626210	D6RCS6 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 6.9 kDa	No	0
TARS-202 ENSP00000486068 ENST00000627006	D6RHV7 [Direct mapping] Threonine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.