Cell atlas - NUP155 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NUP155
Gene description	Nucleoporin 155kDa
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA037775
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane.

Main location

Nuclear membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037775	A-431	Nuclear membrane
HPA037775	U-2 OS	Nuclear membrane
HPA037775	U-251 MG	Nuclear membrane

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA037775

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

74%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA037775	siRNA 1	U-2 OS
		HPA037775	scrambled	U-2 OS

GENE INFORMATION
Gene name	NUP155 (HGNC Symbol)
Synonyms	KIAA0791, N155
Description	Nucleoporin 155kDa (HGNC Symbol)
Entrez gene summary	Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	37288137 - 37371181
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113569 (version 83.38)
Entrez gene	9631
UniProt	O75694 (UniProt - Evidence at protein level)
neXtProt	NX_O75694
Antibodypedia	NUP155 antibodies

PROTEIN BROWSER

NUP155-001	NUP155-003	NUP155-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUP155-001 ENSP00000231498 ENST00000231498	O75694 [Direct mapping] Nuclear pore complex protein Nup155 A0A024R071 [Target identity:100%; Query identity:100%] Nucleoporin 155kDa, isoform CRA_a Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005975 [carbohydrate metabolic process] GO:0006406 [mRNA export from nucleus] GO:0006606 [protein import into nucleus] GO:0006998 [nuclear envelope organization] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0017056 [structural constituent of nuclear pore] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0031965 [nuclear membrane] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0086014 [atrial cardiac muscle cell action potential] GO:1900034 [regulation of cellular response to heat] Show all	1391 aa 155.2 kDa	Yes	0
NUP155-003 ENSP00000422019 ENST00000513532	E9PF10 [Direct mapping] Nuclear pore complex protein Nup155 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006913 [nucleocytoplasmic transport] GO:0017056 [structural constituent of nuclear pore] Show all	1327 aa 148.1 kDa	Yes	0
NUP155-004 ENSP00000371265 ENST00000381843	O75694 [Direct mapping] Nuclear pore complex protein Nup155 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005975 [carbohydrate metabolic process] GO:0006998 [nuclear envelope organization] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0017056 [structural constituent of nuclear pore] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0031965 [nuclear membrane] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:1900034 [regulation of cellular response to heat] Show all	1332 aa 149 kDa	No	0