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H2AFY

CANCER ATLAS

Gene description

 H2A histone family, member Y

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041189

GENE INFORMATION

Gene name

 H2AFY (HGNC Symbol)

Synonyms

 macroH2A1.2

Description

 H2A histone family, member Y (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 135333900 - 135399914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113648 (version 83.38)

Entrez gene

 9555

UniProt

 O75367 (UniProt - Evidence at protein level)

neXtProt

 NX_O75367

Antibodypedia

 H2AFY antibodies

PROTEIN BROWSER
H2AFY-001
H2AFY-002
H2AFY-003
H2AFY-004
H2AFY-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H2AFY-001
ENSP00000423563
ENST00000511689
O75367 [Direct mapping]
Core histone macro-H2A.1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000182 [rDNA binding]
GO:0000228 [nuclear chromosome]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0000793 [condensed chromosome]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001739 [sex chromatin]
GO:0001740 [Barr body]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005730 [nucleolus]
GO:0006334 [nucleosome assembly]
GO:0007549 [dosage compensation]
GO:0010385 [double-stranded methylated DNA binding]
GO:0016568 [chromatin modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031490 [chromatin DNA binding]
GO:0031492 [nucleosomal DNA binding]
GO:0033128 [negative regulation of histone phosphorylation]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045815 [positive regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0070062 [extracellular exosome]
GO:0071169 [establishment of protein localization to chromatin]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]
GO:1902750 [negative regulation of cell cycle G2/M phase transition]
Show all
 372 aa
39.6 kDa 		No 0
H2AFY-002
ENSP00000310169
ENST00000312469
O75367 [Direct mapping]
Core histone macro-H2A.1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000182 [rDNA binding]
GO:0000228 [nuclear chromosome]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001739 [sex chromatin]
GO:0001740 [Barr body]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005730 [nucleolus]
GO:0006334 [nucleosome assembly]
GO:0007549 [dosage compensation]
GO:0010385 [double-stranded methylated DNA binding]
GO:0016568 [chromatin modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031490 [chromatin DNA binding]
GO:0031492 [nucleosomal DNA binding]
GO:0033128 [negative regulation of histone phosphorylation]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045815 [positive regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0070062 [extracellular exosome]
GO:0071169 [establishment of protein localization to chromatin]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]
GO:1902750 [negative regulation of cell cycle G2/M phase transition]
Show all
 369 aa
39.2 kDa 		No 0
H2AFY-003
ENSP00000415121
ENST00000423969
B4DJC3 [Direct mapping]
Histone H2A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 200 aa
21.5 kDa 		No 0
H2AFY-004
ENSP00000302572
ENST00000304332
O75367 [Direct mapping]
Core histone macro-H2A.1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000182 [rDNA binding]
GO:0000228 [nuclear chromosome]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001739 [sex chromatin]
GO:0001740 [Barr body]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005730 [nucleolus]
GO:0006334 [nucleosome assembly]
GO:0007549 [dosage compensation]
GO:0010385 [double-stranded methylated DNA binding]
GO:0016568 [chromatin modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031490 [chromatin DNA binding]
GO:0031492 [nucleosomal DNA binding]
GO:0033128 [negative regulation of histone phosphorylation]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045815 [positive regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0070062 [extracellular exosome]
GO:0071169 [establishment of protein localization to chromatin]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]
GO:1902750 [negative regulation of cell cycle G2/M phase transition]
Show all
 371 aa
39.5 kDa 		No 0
H2AFY-005
ENSP00000424971
ENST00000510038
O75367 [Direct mapping]
Core histone macro-H2A.1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000182 [rDNA binding]
GO:0000228 [nuclear chromosome]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001739 [sex chromatin]
GO:0001740 [Barr body]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005730 [nucleolus]
GO:0006334 [nucleosome assembly]
GO:0007549 [dosage compensation]
GO:0010385 [double-stranded methylated DNA binding]
GO:0016568 [chromatin modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031490 [chromatin DNA binding]
GO:0031492 [nucleosomal DNA binding]
GO:0033128 [negative regulation of histone phosphorylation]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045815 [positive regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0070062 [extracellular exosome]
GO:0071169 [establishment of protein localization to chromatin]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]
GO:1902750 [negative regulation of cell cycle G2/M phase transition]
Show all
 372 aa
39.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.