Expression of BNIP1 in cancer - Summary

CANCER ATLAS

Gene description

BCL2/adenovirus E1B 19kDa interacting protein 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008009

GENE INFORMATION
Gene name	BNIP1 (HGNC Symbol)
Synonyms	Nip1, SEC20
Description	BCL2/adenovirus E1B 19kDa interacting protein 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	173144442 - 173164387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113734 (version 83.38)
Entrez gene	662
UniProt	Q12981 (UniProt - Evidence at protein level)
neXtProt	NX_Q12981
Antibodypedia	BNIP1 antibodies

PROTEIN BROWSER

BNIP1-001	BNIP1-002	BNIP1-003	BNIP1-004	BNIP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP1-001 ENSP00000239215 ENST00000351486	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	228 aa 26.1 kDa	No	1
BNIP1-002 ENSP00000231668 ENST00000231668	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	271 aa 31.1 kDa	No	1
BNIP1-003 ENSP00000377365 ENST00000393770	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	194 aa 22.4 kDa	No	1
BNIP1-004 ENSP00000239214 ENST00000352523	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	237 aa 27.3 kDa	No	1
BNIP1-005 ENSP00000429717 ENST00000519459	H0YBK7 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.4 kDa	No	0