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KNG1

GENERAL INFORMATION

Gene name

 KNG1

Gene description

 Kininogen 1

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (liver, kidney)
GTEx:Group enriched (liver, kidney)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in plasma and in several cases extracellular matrix along with cytoplasmic expression in kidney.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 3 antibodies.
HPA001616 , HPA001645 , CAB009809
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 KNG1 (HGNC Symbol)

Synonyms

 BDK, BK, KNG

Description

 Kininogen 1 (HGNC Symbol)

Entrez gene summary

 This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]

Chromosome

 3

Cytoband

 q27.3

Chromosome location (bp)

 186717276 - 186743954

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113889 (version 83.38)

Entrez gene

 3827

UniProt

 P01042 (UniProt - Evidence at protein level)

neXtProt

 NX_P01042

Antibodypedia

 KNG1 antibodies

PROTEIN BROWSER
KNG1-001
KNG1-002
KNG1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KNG1-001
ENSP00000287611
ENST00000287611
P01042 [Direct mapping]
Kininogen-1 Kininogen-1 heavy chain T-kinin Bradykinin Lysyl-bradykinin Kininogen-1 light chain Low molecular weight growth-promoting factor
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030195 [negative regulation of blood coagulation]
GO:0031093 [platelet alpha granule lumen]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042311 [vasodilation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045861 [negative regulation of proteolysis]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 427 aa
47.9 kDa 		Yes 0
KNG1-002
ENSP00000265023
ENST00000265023
P01042 [Direct mapping]
Kininogen-1 Kininogen-1 heavy chain T-kinin Bradykinin Lysyl-bradykinin Kininogen-1 light chain Low molecular weight growth-promoting factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030195 [negative regulation of blood coagulation]
GO:0031093 [platelet alpha granule lumen]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042311 [vasodilation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045861 [negative regulation of proteolysis]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 644 aa
72 kDa 		Yes 0
KNG1-004
ENSP00000396025
ENST00000447445
P01042 [Direct mapping]
Kininogen-1 Kininogen-1 heavy chain T-kinin Bradykinin Lysyl-bradykinin Kininogen-1 light chain Low molecular weight growth-promoting factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030195 [negative regulation of blood coagulation]
GO:0031093 [platelet alpha granule lumen]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042311 [vasodilation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045861 [negative regulation of proteolysis]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 391 aa
43.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.