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ARL6

CANCER ATLAS

Gene description

 ADP-ribosylation factor-like 6

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019361

GENE INFORMATION

Gene name

 ARL6 (HGNC Symbol)

Synonyms

 BBS3, RP55

Description

 ADP-ribosylation factor-like 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246). [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 97764521 - 97801242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113966 (version 83.38)

Entrez gene

 84100

UniProt

 Q9H0F7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0F7

Antibodypedia

 ARL6 antibodies

PROTEIN BROWSER
ARL6-001
ARL6-004
ARL6-006
ARL6-007
ARL6-201
ARL6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL6-001
ENSP00000419619
ENST00000463745
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010842 [retina layer formation]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0045444 [fat cell differentiation]
GO:0046872 [metal ion binding]
GO:0046909 [intermembrane transport]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097499 [protein localization to nonmotile primary cilium]
Show all
 186 aa
21.1 kDa 		No 0
ARL6-004
ENSP00000418740
ENST00000462412
C9IZ13 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 121 aa
13.7 kDa 		No 0
ARL6-006
ENSP00000419934
ENST00000476753
H7C5H6 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 54 aa
6.3 kDa 		No 0
ARL6-007
ENSP00000488530
ENST00000631834
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 147 aa
17 kDa 		No 0
ARL6-201
ENSP00000337722
ENST00000335979
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007601 [visual perception]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 186 aa
21.1 kDa 		No 0
ARL6-202
ENSP00000377756
ENST00000394206
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007601 [visual perception]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 186 aa
21.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.