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ARL6

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GENERAL INFORMATION

Gene name

 ARL6

Gene description

 ADP-ribosylation factor-like 6

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm & vesicles.

RNA cell category

 Cell line enhanced (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA019361
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm & vesicles.

Main location

 Nucleoplasm (approved), Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019361 A-431 Nucleoplasm
Vesicles
HPA019361 U-2 OS Nucleoplasm
Vesicles
HPA019361 U-251 MG Nucleoplasm
Vesicles

GENE INFORMATION

Gene name

 ARL6 (HGNC Symbol)

Synonyms

 BBS3, RP55

Description

 ADP-ribosylation factor-like 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246). [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 97764521 - 97801242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113966 (version 83.38)

Entrez gene

 84100

UniProt

 Q9H0F7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0F7

Antibodypedia

 ARL6 antibodies

PROTEIN BROWSER
ARL6-001
ARL6-004
ARL6-006
ARL6-007
ARL6-201
ARL6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL6-001
ENSP00000419619
ENST00000463745
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010842 [retina layer formation]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0045444 [fat cell differentiation]
GO:0046872 [metal ion binding]
GO:0046909 [intermembrane transport]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097499 [protein localization to nonmotile primary cilium]
Show all
 186 aa
21.1 kDa 		No 0
ARL6-004
ENSP00000418740
ENST00000462412
C9IZ13 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 121 aa
13.7 kDa 		No 0
ARL6-006
ENSP00000419934
ENST00000476753
H7C5H6 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
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 54 aa
6.3 kDa 		No 0
ARL6-007
ENSP00000488530
ENST00000631834
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 147 aa
17 kDa 		No 0
ARL6-201
ENSP00000337722
ENST00000335979
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007601 [visual perception]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 186 aa
21.1 kDa 		No 0
ARL6-202
ENSP00000377756
ENST00000394206
Q9H0F7 [Direct mapping]
ADP-ribosylation factor-like protein 6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005879 [axonemal microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006612 [protein targeting to membrane]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007368 [determination of left/right symmetry]
GO:0007601 [visual perception]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0030117 [membrane coat]
GO:0032402 [melanosome transport]
GO:0034464 [BBSome]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051258 [protein polymerization]
GO:0060170 [ciliary membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
Show all
 186 aa
21.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.