Expression of PCCB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Propionyl CoA carboxylase, beta polypeptide

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036939	HPA036940

GENE INFORMATION
Gene name	PCCB
Synonyms
Description	Propionyl CoA carboxylase, beta polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Chromosome	3
Cytoband	q22.3
Chromosome location (bp)	136250306 - 136337896
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114054 (version 83.38)
Entrez gene	5096
UniProt	P05166 (UniProt - Evidence at protein level)
neXtProt	NX_P05166
Antibodypedia	PCCB antibodies

PROTEIN BROWSER

PCCB-001	PCCB-002	PCCB-003	PCCB-006	PCCB-007	PCCB-008	PCCB-009	PCCB-010	PCCB-011	PCCB-013	PCCB-014	PCCB-017	PCCB-018	PCCB-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCCB-001 ENSP00000251654 ENST00000251654	P05166 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004658 [propionyl-CoA carboxylase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006635 [fatty acid beta-oxidation] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0016874 [ligase activity] GO:0019626 [short-chain fatty acid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	539 aa 58.2 kDa	Yes	0
PCCB-002 ENSP00000417549 ENST00000471595	E9PDR0 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	550 aa 59.4 kDa	Yes	0
PCCB-003 ENSP00000419027 ENST00000469217	P05166 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004658 [propionyl-CoA carboxylase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006635 [fatty acid beta-oxidation] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0016874 [ligase activity] GO:0019626 [short-chain fatty acid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	559 aa 60.5 kDa	Yes	0
PCCB-006 ENSP00000420759 ENST00000478469	E7ENC1 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	303 aa 32.5 kDa	Yes	0
PCCB-007 ENSP00000418307 ENST00000490504	E7ETT4 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	482 aa 52.4 kDa	Yes	0
PCCB-008 ENSP00000420639 ENST00000483687	E7ETT1 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	520 aa 56.3 kDa	Yes	0
PCCB-009 ENSP00000419129 ENST00000468777	E7EX59 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	570 aa 61.7 kDa	Yes	0
PCCB-010 ENSP00000420391 ENST00000462637	E7EUY3 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	516 aa 55.7 kDa	Yes	0
PCCB-011 ENSP00000420158 ENST00000466072	C9JQS9 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	559 aa 60.7 kDa	Yes	0
PCCB-013 ENSP00000417253 ENST00000482086	E9PEC3 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	423 aa 45.4 kDa	Yes	0
PCCB-014 ENSP00000419263 ENST00000465423	C9JVY9 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	192 aa 20.4 kDa	Yes	0
PCCB-017 ENSP00000419563 ENST00000462542	H7C5C9 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003989 [acetyl-CoA carboxylase activity] GO:0006633 [fatty acid biosynthetic process] GO:0009317 [acetyl-CoA carboxylase complex] GO:0016874 [ligase activity] Show all	163 aa 17.1 kDa	No	0
PCCB-018 ENSP00000418020 ENST00000494742	C9JAW3 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	84 aa 8.9 kDa	No	0
PCCB-019 ENSP00000419293 ENST00000459873	C9JVW9 [Direct mapping] Propionyl-CoA carboxylase beta chain, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003989 [acetyl-CoA carboxylase activity] GO:0006633 [fatty acid biosynthetic process] GO:0009317 [acetyl-CoA carboxylase complex] GO:0016874 [ligase activity] Show all	134 aa 14 kDa	No	0