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GNAT1

CANCER ATLAS

Gene description

 Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045393

GENE INFORMATION

Gene name

 GNAT1 (HGNC Symbol)

Synonyms

 CSNBAD3

Description

 Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (HGNC Symbol)

Entrez gene summary

 Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 50191612 - 50196516

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114349 (version 83.38)

Entrez gene

 2779

UniProt

 P11488 (UniProt - Evidence at protein level)

neXtProt

 NX_P11488

Antibodypedia

 GNAT1 antibodies

PROTEIN BROWSER
GNAT1-001
GNAT1-002
GNAT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAT1-001
ENSP00000232461
ENST00000232461
P11488 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
A0A024R2Z1 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, isoform CRA_a
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000035 [acyl binding]
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0001664 [G-protein coupled receptor binding]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009416 [response to light stimulus]
GO:0009642 [response to light intensity]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0019901 [protein kinase binding]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0032391 [photoreceptor connecting cilium]
GO:0042462 [eye photoreceptor cell development]
GO:0042622 [photoreceptor outer segment membrane]
GO:0043025 [neuronal cell body]
GO:0046872 [metal ion binding]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0050917 [sensory perception of umami taste]
GO:0051343 [positive regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0060041 [retina development in camera-type eye]
GO:0071257 [cellular response to electrical stimulus]
GO:0097381 [photoreceptor disc membrane]
Show all
 350 aa
40 kDa 		No 0
GNAT1-002
ENSP00000387555
ENST00000433068
P11488 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
A0A024R2Z1 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, isoform CRA_a
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000035 [acyl binding]
GO:0001664 [G-protein coupled receptor binding]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0009416 [response to light stimulus]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0019901 [protein kinase binding]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0042622 [photoreceptor outer segment membrane]
GO:0046872 [metal ion binding]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0050917 [sensory perception of umami taste]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0097381 [photoreceptor disc membrane]
Show all
 350 aa
40 kDa 		No 0
GNAT1-003
ENSP00000403537
ENST00000440836
C9JCV8 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
Show all
Predicted intracellular proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0050917 [sensory perception of umami taste]
Show all
 130 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.