We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
GNAT1
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GNAT1

Gene description

Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (retina)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in rods in retina.

DATA RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

Supported based on 1 antibody.
HPA045393
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinRetinaNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0246810TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,000Tags Per Million

GENE INFORMATION

Gene name

GNAT1 (HGNC Symbol)

Synonyms

CSNBAD3

Description

Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (HGNC Symbol)

Entrez gene summary

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

50191612 - 50196516

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114349 (version 83.38)

Entrez gene

2779

UniProt

P11488 (UniProt - Evidence at protein level)

neXtProt

NX_P11488

Antibodypedia

GNAT1 antibodies

PROTEIN BROWSER

GNAT1-001
GNAT1-002
GNAT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GNAT1-001
ENSP00000232461
ENST00000232461
P11488 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
A0A024R2Z1 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, isoform CRA_a
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000035 [acyl binding]
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0001664 [G-protein coupled receptor binding]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009416 [response to light stimulus]
GO:0009642 [response to light intensity]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0019901 [protein kinase binding]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0032391 [photoreceptor connecting cilium]
GO:0042462 [eye photoreceptor cell development]
GO:0042622 [photoreceptor outer segment membrane]
GO:0043025 [neuronal cell body]
GO:0046872 [metal ion binding]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0050917 [sensory perception of umami taste]
GO:0051343 [positive regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0060041 [retina development in camera-type eye]
GO:0071257 [cellular response to electrical stimulus]
GO:0097381 [photoreceptor disc membrane]
Show all
350 aa
40 kDa
No 0
GNAT1-002
ENSP00000387555
ENST00000433068
P11488 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
A0A024R2Z1 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, isoform CRA_a
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000035 [acyl binding]
GO:0001664 [G-protein coupled receptor binding]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0009416 [response to light stimulus]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0019901 [protein kinase binding]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0042622 [photoreceptor outer segment membrane]
GO:0046872 [metal ion binding]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0050917 [sensory perception of umami taste]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0097381 [photoreceptor disc membrane]
Show all
350 aa
40 kDa
No 0
GNAT1-003
ENSP00000403537
ENST00000440836
C9JCV8 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-1
Show all
Predicted intracellular proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0050917 [sensory perception of umami taste]
Show all
130 aa
14.8 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.