Cell atlas - NPRL2 - The Human Protein Atlas

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NPRL2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	NPRL2
Gene description	NPR2-like, GATOR1 complex subunit
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA038196 , HPA038197
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038196	A-431	Plasma membrane
HPA038196	A-431	Cytosol
HPA038196	U-251 MG	Cytosol
HPA038197	A-431	Cytosol
HPA038197	PC-3	Microtubules
HPA038197	PC-3	Cytosol
HPA038197	U-2 OS	No staining

GENE INFORMATION
Gene name	NPRL2 (HGNC Symbol)
Synonyms	NPR2, NPR2L, TUSC4
Description	NPR2-like, GATOR1 complex subunit (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	50347330 - 50351091
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114388 (version 83.38)
Entrez gene	10641
UniProt	Q8WTW4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WTW4
Antibodypedia	NPRL2 antibodies

PROTEIN BROWSER

NPRL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPRL2-001 ENSP00000232501 ENST00000232501	Q8WTW4 [Direct mapping] Nitrogen permease regulator 2-like protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0006468 [protein phosphorylation] GO:0032007 [negative regulation of TOR signaling] GO:0033673 [negative regulation of kinase activity] GO:0034198 [cellular response to amino acid starvation] GO:0043547 [positive regulation of GTPase activity] GO:1990130 [Iml1 complex] Show all	380 aa 43.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.